Overview
- Alexander Zverev defeated Alejandro Davidovich Fokina in a tight three-set match, leaving the Madrid Open without any Spanish singles players.
- Francisco Cerúndolo secured a straight-sets victory over compatriot Francisco Comesaña to advance to the round of 16, where he will face top-seeded Zverev.
- Defending champion Andrey Rublev was upset by Alexander Bublik in a three-set battle, marking a disappointing end to his title defense.
- Daniil Medvedev cruised past Juan Manuel Cerúndolo with a dominant 6-2, 6-2 win, setting up a round of 16 clash with Brandon Nakashima.
- Aryna Sabalenka overcame an early set loss to defeat Elise Mertens and advance in the women's draw, where she will face Peyton Stearns.