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4d ago

AI Pinpoints Gut Microbiome Signature to Diagnose Chronic Pain Syndrome with 90% Accuracy

Groundbreaking research identifies a persistent microbiome marker for CRPS, paving the way for earlier diagnosis and new treatment strategies.

The research identified significant differences between the gut bacteria of CRPS patients and pain-free individuals. Credit: Neuroscience News

Overview

  • Researchers from McGill University, Israel, and Ireland developed AI technology to diagnose complex regional pain syndrome (CRPS) using gut microbiome data.
  • The AI model achieved over 90% accuracy in identifying CRPS across patient cohorts in Canada and Israel, despite geographic and lifestyle differences.
  • A universal gut microbiome signature linked to CRPS was found to persist even in patients whose symptoms resolved after limb amputation, suggesting a predisposition rooted in the microbiome.
  • The study, published in the journal *Anesthesiology*, is one of the largest investigations into the gut microbiome and chronic pain, analyzing 120 microbiome and over 100 plasma samples.
  • The findings highlight the potential for microbiome-based diagnostics and treatments, offering hope for earlier intervention and improved care for CRPS patients.