Overview

• Researchers developed an AI tool that analyzes gut microbiome data to diagnose CRPS with over 90% accuracy across Israeli and Canadian cohorts.
• The study identified a consistent gut microbiome signature in CRPS patients, persisting even after symptom resolution, such as post-amputation.
• This persistent microbial pattern suggests a predisposition to CRPS, potentially enabling earlier diagnosis and personalized treatment strategies.
• The findings, published in the journal *Anesthesiology*, are based on one of the largest microbiome studies in chronic pain, analyzing 120 microbiome and over 100 plasma samples.
• The research highlights the potential for microbiome-based diagnostics and therapies in managing CRPS and other chronic pain conditions.