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AI Eye-Tracking Spots Preclinical Alzheimer’s in Familial Mutation Carriers With Near-Perfect Accuracy

The Brain Communications paper evaluated ViewMind Atlas in Colombian families carrying an inherited mutation that leads to Alzheimer’s.

Overview

  • ViewMind Atlas identified symptomatic carriers with 100% accuracy and asymptomatic carriers with 96%, according to the study.
  • Participants came from extended families in Colombia known to carry a deterministic Alzheimer’s mutation.
  • The system pairs eye-tracking with Software as a Medical Device to analyze brain function during a visual short-term memory binding task.
  • The AI framework used a Random Forest classifier to distinguish groups based on the presence or likelihood of Alzheimer’s.
  • Researchers say the non-invasive approach may outperform traditional cognitive tests, offer a potential preclinical biomarker, and enable monitoring over time, with further validation still needed.