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AI ECG Screening Tools Enter Clinical Trials After Outperforming Doctors

Trained on millions of ECG–echocardiogram pairs with international validation, these AI-driven ECG tools promise earlier detection of structural and valvular heart disease.

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A message reading "AI artificial intelligence", a keyboard, and robot hands are seen in this illustration taken January 27, 2025. REUTERS/Dado Ruvic/Illustration/File Photo
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Overview

  • EchoNext achieved 77% accuracy versus 64% for 13 cardiologists in detecting structural heart disease on 3,200 ECGs, according to results published in Nature.
  • Clinical trials of EchoNext have launched in eight emergency departments to evaluate its ability to triage patients for echocardiography in real-world settings.
  • Imperial College London’s valvular disease algorithm demonstrated 69–79% accuracy in predicting regurgitant valve defects and flagged high-risk individuals who were up to ten times more likely to develop disease.
  • Imperial’s model was trained on nearly 1 million ECG–echocardiogram records from over 400,000 Chinese patients and validated on more than 34,000 US patients to confirm its cross-population reliability.
  • By augmenting routine ECGs with AI, these tools aim to shift cardiac care toward proactive screening and earlier intervention for asymptomatic structural and valvular conditions.