Overview
- Using Mendelian randomization, the team tested genetic proxies for fasting glucose, insulin, and two‑hour post‑meal glucose to assess likely causal effects on dementia.
- Elevated two‑hour post‑prandial glucose emerged as the standout signal associated with Alzheimer’s risk in the analysis.
- The association was not explained by global brain volume or white‑matter damage, pointing to other biological pathways.
- The authors urge replication in diverse ancestries before the findings inform clinical advice or public‑health guidance.
- The peer‑reviewed study in Diabetes, Obesity and Metabolism highlights post‑meal glucose control as a potential prevention focus.