Overview

• Scientists developed a multiplexed suspension bead array immunoassay to study GPCR-RAMP interactions.
• The method allows simultaneous screening of hundreds of GPCR-RAMP complexes, revealing 122 significant interactions.
• The findings increase known GPCR-RAMP interactions by an order of magnitude, aiding in selective therapeutic design.
• Publicly available resources now include libraries of anti-GPCR antibodies and engineered GPCR genes.
• The research provides insights into why some GPCR-targeting drugs fail and identifies natural ligands for orphan GPCRs.