Overview

• The Science study combined single-nucleus RNA sequencing, spatial transcriptomics and validated machine-learning models to identify neural progenitor cells.
• Researchers localized dividing progenitors and immature neurons specifically to the dentate gyrus region of the hippocampus.
• Progenitor cells were detected in donors aged 20 to 78, demonstrating ongoing neurogenesis across a wide adult age span.
• The molecular fingerprints pinpointed by the study resolve decades of conflicting evidence on whether adult human hippocampi generate new neurons.
• Research is now focusing on individual variability in neurogenesis and evaluating regenerative strategies for neurodegenerative and psychiatric disorders.