Overview

• The American College of Cardiology released its Scientific Statement, Inflammation and Cardiovascular Disease, with publication in JACC on September 29, 2025.
• The statement affirms that systemic inflammation contributes to conditions such as coronary artery disease and heart failure.
• High-sensitivity C-reactive protein is identified as an inexpensive, widely available test with demonstrated value for clinical decision making in both primary and secondary prevention.
• For patients with established cardiovascular disease, hsCRP is at least as predictive of future events as LDL cholesterol, including among those on statin therapy.
• Recommended measures to reduce inflammation include at least 150 minutes per week of exercise, Mediterranean or DASH dietary patterns, and two to three weekly servings of fatty fish rich in EPA and DHA.