AAP 2025 Review: COVID Vaccination in Pregnancy Tied to Lower Infection and Better Neonatal Outcomes

Overview

• The analysis estimated a 58% reduction in maternal SARS-CoV-2 infection among vaccinated pregnant people.
• Risks fell for preterm birth by 8% before 37 weeks and 34% before 28 weeks, with stillbirth 25% lower.
• Neonatal intensive care admission dropped by about 9%, and congenital anomalies by 17%, in pooled results.
• No increased risks were detected for maternal hospitalization, ICU admission, gestational diabetes, hypertension, or pre-eclampsia, though cesarean delivery rose slightly (RR 1.07).
• The umbrella review searched major databases through September 13, 2023, was PROSPERO-registered, reported no external funding, and was presented at the American Academy of Pediatrics meeting in Denver.