Overview
- Carolina ruled out center Cade Mays (ankle) and inside linebackers Christian Rozeboom (hip/hamstring) and Trevin Wallace (shoulder), with Austin Corbett set to start at center.
- San Francisco ruled out linebacker Tatum Bethune (ankle) and kicker Eddy Piñeiro (right hamstring), and Matt Gay will handle kicking duties after a planned practice-squad elevation.
- Brock Purdy practiced fully all week and carries no injury designation, while Bryce Young was a full participant and is cleared to play.
- Christian McCaffrey, the NFL leader in touches and scrimmage yards entering Week 12, faces the Panthers for the first time since his 2022 trade.
- The Panthers enter their first prime-time game in over two years with another offensive line shuffle, marking their ninth starting combination this season.