Overview
- San Francisco outscored Cleveland 16-0 after halftime, with Brock Purdy totaling a rushing touchdown and a scoring pass to Jauan Jennings as Christian McCaffrey added a 1-yard TD.
- Rookie quarterback Shedeur Sanders went 16-of-25 for 149 yards with one touchdown and no turnovers in his first home start, and the Browns fell to 3-9.
- Myles Garrett recorded one sack on Purdy, pushing his NFL-leading total to 19 this season.
- The 49ers reported injuries to Nick Martin (concussion), Ben Bartch (foot) and Kyle Juszczyk (rib), with Kyle Shanahan saying initial checks showed no fracture for Juszczyk and further tests planned; Browns DT Maliek Collins was carted off with a knee injury.
- Steelers coach Mike Tomlin said Aaron Rodgers had no injury designation and practiced fully for Buffalo, while Ian Rapoport reported Rodgers is set to play despite at least three fractures in his left wrist.