Overview

• Kickoff is set for Sunday, Sept. 21 at 4:25 p.m. ET (1:25 p.m. PT) at Levi’s Stadium on FOX.
• San Francisco is listed as roughly a 1.5-point favorite in early Week 3 odds from major sportsbooks.
• Kyle Shanahan said Brock Purdy has a chance to play after Mac Jones started in Week 2 and threw three touchdowns for 279 yards.
• Arizona is managing multiple injuries in the secondary and placed safety Joey Blount on injured reserve with a season-ending neck injury.
• The Cardinals released a largely unchanged Week 3 depth chart despite the injuries, reflecting minimal adjustments heading into the divisional game.