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49ers vs. Cardinals Kicks Off at 4:25 p.m. ET on FOX as Mac Jones Is Expected to Start

Brock Purdy remains questionable with a toe injury, and the 2-0 divisional matchup opens with San Francisco a slight favorite.

Overview

  • The game is at Levi's Stadium in Santa Clara with a national FOX broadcast; local viewers can watch on KTVU (San Francisco) and KSAZ (Phoenix), with streaming on Fubo and out-of-market access via NFL Sunday Ticket on YouTube TV.
  • Head coach Kyle Shanahan said it is “highly unlikely” Purdy will start after limited practice, pointing to Jones after his 279-yard, three-touchdown, zero-interception performance in Week 2.
  • Both teams are 2-0 entering Week 3, giving the matchup early NFC West significance as Kyler Murray leads Arizona into San Francisco’s home opener.
  • Betting lines have the 49ers as a narrow favorite at roughly -1.5 with an over/under near 43.5 points, according to BetMGM.
  • Fantasy guidance is split on Jones, with Niners Wire advising a sit in most formats and SB Nation calling him a viable start given the matchup.