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49ers to Open Season Without Aiyuk as Jennings Remains Sidelined

Lynch emphasised a health-first recovery plan that will require Aiyuk to miss at least four games before a potential Week 6 return.

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Jan 5, 2025; Glendale, Arizona, USA; San Francisco 49ers wide receiver Jauan Jennings (15) is led away from a fight by quarterback Joshua Dobbs (5) against the Arizona Cardinals in the first half at State Farm Stadium.
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Overview

  • General manager John Lynch said there is no exact timetable for Brandon Aiyuk and he is unlikely to be cleared for Week 1 after starting camp on the reserve/PUP list.
  • NFL rules mandate that a reserve/PUP designation forces Aiyuk to miss at least the first four games, making Week 6 against the Buccaneers the earliest realistic comeback.
  • Aiyuk continues to rehab ACL and MCL tears sustained in October 2024 and will progress through milestone-based recovery before rejoining practice.
  • Jauan Jennings has been sidelined since late July by a lingering calf strain with no set return date and has requested a contract extension ahead of entering the final year of his deal.
  • With both veteran receivers out, the 49ers are increasing reps for younger pass-catchers in training camp as they balance depth-chart decisions with cautious rehabilitation.