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49ers to Open Season With Brandon Aiyuk on PUP List Despite Week 1 Return Hints

Insiders point to accelerated rehab progress despite medical analyses favoring a safer midseason comeback.

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Overview

  • Aiyuk signed a four-year, $120 million extension last August making him San Francisco’s No. 1 wide receiver
  • He tore his ACL, MCL and meniscus in Week 7 of the 2024 season, ending his campaign
  • The 49ers plan to place him on the Physically Unable to Perform list to open the season, a move that carries at least a four-game absence
  • Insider Matt Maiocco reports Aiyuk’s knee is ahead of schedule and could be ready by Week 1 of 2025
  • Injury analyst Dr. Deepak Chona warns that "ahead of schedule" rarely predicts an accelerated return and still expects him back around October