Overview
- San Francisco inked veteran running back Jeff Wilson Jr. and defensive end Trevis Gipson to one-year deals to shore up depth.
- Ameer Abdullah was placed on season-ending injured reserve after sustaining a rib injury in the preseason opener against Denver.
- Quarterback Tanner Mordecai was waived to free up a roster spot and offensive tackle Andre Dillard was activated off the physically unable to perform list.
- Shoulder and finger injuries to Isaac Guerendo and Jordan James plus a high-ankle sprain for rookie Jordan Watkins have further depleted the depth chart.
- Christian McCaffrey continues to sit out preseason games as he rehabs a PCL sprain but remains on track for the regular season opener.