Overview

• San Francisco will also be without receivers Ricky Pearsall and Jauan Jennings, with George Kittle on IR, Brandon Aiyuk on PUP and Nick Bosa out for the season.
• Sportsbooks shifted the line to approximately Rams -7 to -7.5 following the injury confirmations, a sizable move from earlier in the week.
• SportsLine’s model highlights major leverage: a Rams loss drops their playoff odds from 59.3% to 41.3%, while a 49ers road win boosts theirs from 57.6% to 72.3%.
• Most expert predictions now back Los Angeles, pointing to the Rams’ healthier lineup and strong form from Matthew Stafford and league-leading receiver Puka Nacua.
• With multiple pass-catchers unavailable on a short week, the 49ers are expected to lean on Christian McCaffrey and a run-heavy, clock-control approach.