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49ers Rule Out Brock Purdy for TNF as Mac Jones Starts, Adrian Martinez Promoted

An MRI-confirmed toe aggravation has Purdy listed week-to-week, prompting San Francisco to reshuffle its quarterback depth for the Rams game.

Aug 22, 2025; East Rutherford, New Jersey, USA; New York Jets quarterback Adrian Martinez (15) rushed for a touchdown during the second half against the Philadelphia Eagles at MetLife Stadium. Mandatory Credit: Vincent Carchietta-Imagn Images/ File Photo
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Rams vs 49ers - NFL Week 5 Thursday Night Football

Overview

  • San Francisco listed Brock Purdy inactive for the Week 5 Thursday Night Football matchup at the Rams, with Mac Jones starting at quarterback.
  • NFL Network’s Ian Rapoport reported an MRI showed an aggravation of Purdy’s turf-toe injury and described his status as week-to-week with no firm timetable.
  • The 49ers signed Adrian Martinez to the 53-man roster to back up Jones, a move some analysts noted could signal uncertainty beyond this week.
  • Top receivers Ricky Pearsall (knee) and Jauan Jennings (ankle, ribs) were ruled out, with George Kittle on injured reserve and Nick Bosa lost for the season.
  • Oddsmakers leaned toward Los Angeles before kickoff, with multiple outlets noting the Rams as more than a touchdown favorite given San Francisco’s injuries.