Overview

• San Francisco’s official report ruled out Brock Purdy (toe), Ricky Pearsall (knee), Jauan Jennings (rib/ankle), Jordan Watkins (calf) and Robert Beal Jr. (ankle) for the primetime game.
• Mac Jones makes his third start of the season after a 2-0 stint in Weeks 2–3, though he’ll work without multiple top receivers as George Kittle remains on IR and Brandon Aiyuk has yet to play in 2025.
• The Rams listed right tackle Rob Havenstein and tight end Tyler Higbee as doubtful, raising questions about Matthew Stafford’s protection and targets.
• Betting markets shifted toward Los Angeles, with lines in the 7 to 8.5 range and broad expert consensus picking the Rams, including a 27–0 tally compiled by The Sporting News.
• In a separate Week 5 line reflecting the health-driven trend, FanDuel has the Bills favored by 8.5 over the Patriots.