Overview

• San Francisco confirmed Brock Purdy (toe), Ricky Pearsall (knee) and Jauan Jennings (ankle, ribs) will not play on Thursday night at SoFi Stadium.
• Mac Jones gets his third start of the season after two earlier wins, having completed about 66% of his passes for 563 yards with four touchdowns and one interception.
• The 49ers’ depth is already strained with George Kittle on injured reserve, Brandon Aiyuk still out and Nick Bosa gone for the season.
• Rams right tackle Rob Havenstein (ankle) and tight end Tyler Higbee (hip) are listed as doubtful, potentially affecting Matthew Stafford’s protection and targets.
• Sportsbooks shifted the spread toward Los Angeles to roughly a touchdown or more, and analysts expect San Francisco to lean on Christian McCaffrey and a clock-control approach.