Overview
- Jacoby Brissett set the NFL regular-season record with 47 completions on 57 attempts for 452 yards with two touchdowns and two interceptions.
- Arizona committed a franchise-record 17 penalties for 130 yards and compounded the damage with special-teams errors and a goal-line fumble.
- Brock Purdy, back from a turf-toe absence, finished 19-of-26 for 200 yards and three touchdowns as Christian McCaffrey logged 121 yards and three scores and George Kittle caught two TDs.
- San Francisco generated three takeaways, including interceptions by Malik Mustapha and Deommodore Lenoir and a forced fumble at the goal line recovered by Keion White.
- Kicker Eddy Piñeiro left with a right hamstring issue after extending his perfect field-goal streak to 22, as the 49ers improved to 7-4 and the Cardinals dropped to 3-7.