Overview
- Mac Jones started with Brock Purdy inactive and went 19-of-24 for 235 yards and two touchdowns after a 14-of-14 first half.
 - Christian McCaffrey produced 173 scrimmage yards and scored both rushing and receiving touchdowns, setting an NFL record with his 16th such game.
 - San Francisco leaned on the ground game with 39 rushes for 159 yards, including an 18-yard touchdown by Brian Robinson Jr., after building a 17-7 halftime lead.
 - Giants rookie Jaxson Dart finished 24-of-33 for 191 yards with two touchdown passes and a rushing score as New York fell to 2-7 amid ongoing injuries.
 - Rookie defensive lineman Mykel Williams left late with a right lower-leg injury that is being evaluated for a possible ACL tear.