Overview
- The San Francisco 49ers officially put running back Isaac Guerendo on the reserve/physically unable to perform list, which removes him from the active roster while he recovers.
- Guerendo missed all of training camp after suffering a torn pectoral muscle in late May and will be ineligible to play for at least the first four regular-season games under the PUP rules.
- The team can bring Guerendo back without using an Injured Reserve slot, which lets the 49ers keep him under contract while freeing a roster spot for immediate needs.
- Christian McCaffrey, Kaelon Black and Jordan James have returned from August injuries, reducing short-term pressure at running back and making the PUP move a practical roster choice.
- The 49ers are expected to shift multiple injured players to Injured Reserve and to use up to two designation-to-return slots, with names like Kurtis Rourke, Mykel Williams, Christian Kirk and Vederian Lowe discussed as candidates.