Overview
- The 7-4 49ers host the 6-5 Panthers on Monday Night Football at Levi’s Stadium in Santa Clara.
- Christian McCaffrey said he is taking the matchup very seriously and enters as the league leader with 1,439 scrimmage yards and 11 touchdowns.
- San Francisco is chasing ground in a tight NFC West race, while Carolina remains firmly in the playoff picture after a Week 11 overtime win.
- Carolina’s offense has surged under Dave Canales, highlighted by Bryce Young’s franchise-record 448 passing yards in Week 11 and Tetairoa McMillan’s emergence.
- Preview coverage projects a close game, with ClutchPoints predicting a narrow 49ers win by scores such as 27-23 or 30-24.