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49ers Overcome Purdy’s Picks to Beat Panthers 20-9 on Monday Night Football

Defensive takeaways powered San Francisco's 8-4 push behind Christian McCaffrey's 142 yards.

SANTA CLARA, CALIFORNIA - NOVEMBER 24: Christian McCaffrey #23 of the San Francisco 49ers runs into the end zone for a touchdown in the third quarter of the game against the Carolina Panthers at Levi's Stadium on November 24, 2025 in Santa Clara, California. (Photo by Thien-An Truong/Getty Images)
Jauan Jennings (L) is separated from Tre'von Moehrig (R) after the game.
SANTA CLARA, CALIFORNIA - NOVEMBER 24: Brock Purdy #13 of the San Francisco 49ers runs onto the field prior to the game against the Carolina Panthers at Levi's Stadium on November 24, 2025 in Santa Clara, California. (Photo by Thien-An Truong/Getty Images)
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Overview

  • Brock Purdy threw three first-half interceptions but finished 23-of-32 for 192 yards with one touchdown.
  • Christian McCaffrey totaled 142 scrimmage yards and scored on a 12-yard run in his first game against his former team.
  • Safety Ji'Ayir Brown intercepted Bryce Young twice, and Carolina managed only three points off San Francisco's three turnovers.
  • Newly signed kicker Matt Gay went 4-for-4 on kicks, including field goals from 47 and 29 yards.
  • The result moved San Francisco to 8-4 and dropped Carolina to 6-6, with the Panthers losing Jaycee Horn to a reported concussion and a brief postgame Jennings–Moehrig altercation potentially drawing league review.