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49ers Open Malik Mustapha’s 21-Day Practice Window, Setting Up Potential Midseason Return

The 21-day clock forces San Francisco to decide on activating the second-year safety after January ACL graft surgery.

Overview

  • San Francisco opened Mustapha’s practice window on Oct. 6, and he took part in individual work during a bonus session.
  • Under PUP rules, the team has 21 days to add him to the 53-man roster or place him on season-ending injured reserve.
  • He could be eligible to play as soon as Week 6 against the Buccaneers, though coaches have stressed patience with ACL timelines.
  • Mustapha underwent surgery in January to reattach a graft in his right ACL after being injured in the 2024 season finale.
  • His return would impact a safety rotation featuring Marques Sigle and Jason Pinnock with Ji’Ayir Brown in packages, and teammates hailed his energy, calling him a “human bullet.”