Overview

• San Francisco begins Week 1 at Lumen Field with a defense expected to lean heavily on first-year players, with reports indicating as many as six rookie starters.
• Robert Saleh returns as defensive coordinator and frames Seattle’s run game as the revamped unit’s first major test.
• The offseason reset kept only select stars on new deals — Brock Purdy, Fred Warner and George Kittle — while many veterans were replaced by 19 draft picks over two years.
• The team carries more than $100 million in 2025 salary-cap charges for players no longer on the roster.
• Christian McCaffrey cut a practice short with a calf concern he called “nothing serious” and is listed as questionable for the opener.