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49ers' Nick Bosa Tears Right ACL, Out for 2025 Season

Imaging on Monday confirmed a clean tear requiring surgery, sharpening the 49ers’ need to lean on Bryce Huff and rookie Mykel Williams.

Image
Sep 21, 2025; Santa Clara, California, USA; San Francisco 49ers defensive end Nick Bosa (97) on the field during warm ups prior to a game against the Arizona Cardinals during the first half at Levi's Stadium. Mandatory Credit: Cary Edmondson-Imagn Images
Nick Bosa #97 of the San Francisco 49ers stands on the sidelines during the national anthem prior to an NFL football game against the Arizona Cardinals at Levi's Stadium on September 21, 2025 in Santa Clara, California.

Overview

  • Bosa injured his right knee late in the first quarter of Sunday’s 16-15 win over the Cardinals and walked to the locker room after giving a thumbs-down sign.
  • Kyle Shanahan said additional tests confirmed a season-ending ACL tear with no meniscus or other ligament damage, describing it as “as clean as it gets.”
  • This is Bosa’s second NFL season lost to an ACL tear after damaging his left knee in 2020, and he also had a partial right ACL tear in high school.
  • Veteran Bryce Huff will take over starting edge duties, with first-round pick Mykel Williams and other depth pieces expected to play larger roles in a committee approach.
  • San Francisco is 3-0 but already managing injuries to key contributors including Brock Purdy (toe), George Kittle (hamstring, IR) and Jauan Jennings (shoulder/ankle), and the team is evaluating possible roster moves.