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49ers’ Nick Bosa Tears ACL, Will Miss Remainder of 2025 Season

MRI showed a clean right‑knee tear with no other ligament damage, signaling a straightforward surgery‑rehab plan.

Sep 21, 2025; Santa Clara, California, USA; San Francisco 49ers defensive end Nick Bosa (97) on the field during warm ups prior to a game against the Arizona Cardinals during the first half at Levi's Stadium. Mandatory Credit: Cary Edmondson-Imagn Images
Nick Bosa #97 of the San Francisco 49ers stands on the sidelines during the national anthem prior to an NFL football game against the Arizona Cardinals at Levi's Stadium on September 21, 2025 in Santa Clara, California.
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SANTA CLARA, CALIFORNIA - SEPTEMBER 21: Kyler Murray #1 of the Arizona Cardinals scrambles away from the pressure of CJ West #99 of the San Francisco 49ers during the fourth quarter at Levi's Stadium on September 21, 2025 in Santa Clara, California. (Photo by Thearon W. Henderson/Getty Images)

Overview

  • The injury was confirmed Monday after testing following the Week 3 win over the Cardinals, with season-ending surgery planned.
  • Coach Kyle Shanahan said the tear was described as clean, with the meniscus and other ligaments unaffected.
  • The right-knee injury is Bosa’s second career ACL tear, following a left-knee ACL tear sustained in 2020.
  • San Francisco will reallocate snaps to Bryce Huff, with rookie Mykel Williams and Yetur Gross-Matos among those expected to share the workload.
  • Before exiting, Bosa had compiled 17 tackles, two sacks and two forced fumbles through three games for the 3-0 49ers.