Overview

• Bosa was hurt late in the first quarter when his right leg extended awkwardly while he was double-teamed on a third-down rush.
• He went to the blue medical tent, signaled a thumbs-down to the crowd, briefly tested the knee on the sideline, and then headed to the locker room.
• San Francisco initially listed him as questionable to return with a knee injury before ruling him out at halftime.
• Rookie defensive end Mykel Williams left for a brief wrist evaluation in the first half and returned to the game.
• The 2022 AP Defensive Player of the Year had two sacks through two games and carries a prior history of a season-ending knee injury in 2020.