49ers' Nick Bosa Out for Third Straight Game as Injuries Mount

San Francisco faces Chicago without key players, including Bosa, McCaffrey, and Mason, while Talanoa Hufanga returns to bolster the defense.

Star defensive end Nick Bosa has been ruled out for the third consecutive game due to hip and oblique injuries, leaving a significant gap in the 49ers' defensive line.
The 49ers have placed running backs Christian McCaffrey and Jordan Mason on injured reserve, with rookie Isaac Guerendo stepping in as the team's top healthy back.
Safety Talanoa Hufanga, a 2022 All-Pro, has been activated from injured reserve and is expected to play with a protective cast on his surgically repaired wrist.
Offensive lineman Aaron Banks and left tackle Trent Williams have also been ruled out, adding to the team's growing list of absences.
San Francisco, currently last in the NFC West at 5-7, has lost three straight games and faces an uphill battle to remain competitive in the playoff race.