Overview

• The injury occurred late in the first quarter on a third-and-9 rush when his right leg bent awkwardly while he was double-teamed.
• He was examined in the blue medical tent, appeared in visible discomfort, signaled a thumbs-down to the stands, and then went to the locker room with trainers.
• San Francisco initially listed him as questionable to return before the Associated Press reported he was ruled out at halftime.
• Bosa is a cornerstone of the defense as the 2022 AP Defensive Player of the Year and entered the game with two sacks through two weeks.
• The setback comes as the 49ers manage other injuries to key players, with George Kittle on injured reserve, Brandon Aiyuk on the PUP list, and Brock Purdy and Jauan Jennings previously sidelined, while rookie Mykel Williams briefly left with a wrist issue before returning.