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49ers Navigate Spate of Injuries as Purdy Returns to Practice, Pearsall Expects to Play

San Francisco is evaluating Brock Purdy’s progress this week to stabilize an injury-thinned roster.

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SANTA CLARA, CALIFORNIA - SEPTEMBER 21: Christian McCaffrey #23 of the San Francisco 49ers stands on the field during the first half of an NFL football game against the Arizona Cardinals at Levi's Stadium on September 21, 2025 in Santa Clara, California. (Photo by Brooke Sutton/Getty Images)
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49ers wide receiver Ricky Pearsall catches a 34-yard pass that bounced off his helmet against the Arizona Cardinals’ Kei-Trel Clark in the fourth quarter of San Francisco’s 16-15 win Sunday at Levi’s Stadium.

Overview

  • Preparing for Sunday’s home game against Jacksonville, the 3-0 49ers listed a lengthy Wednesday report with multiple starters either not practicing or limited.
  • Brock Purdy was a limited participant as he works back from a toe injury, with Mac Jones also limited due to a knee issue.
  • Leading receiver Ricky Pearsall sat out with knee soreness but told reporters he plans to practice and would play if the game were today.
  • Jauan Jennings remained sidelined with ankle and shoulder injuries, and rookie Jordan Watkins also did not practice because of a calf issue.
  • With Nick Bosa out for the season after a torn ACL, San Francisco promoted DE Robert Beal Jr., while WR Demarcus Robinson became eligible after a three-game suspension and DT C.J. West had thumb surgery with hope to play in a cast.