Overview

• The official Wednesday report listed 12 San Francisco players as out or limited, with quarterbacks Brock Purdy (toe, shoulder) and Mac Jones (knee) both limited.
• Top receiver Ricky Pearsall did not practice due to knee soreness but said he is not worried and would play if the game were today.
• Star edge rusher Nick Bosa is out for the season with a torn ACL, and the team promoted defensive end Robert Beal Jr. to the active roster.
• Tight end George Kittle remains on injured reserve, while wideouts Jauan Jennings and Jordan Watkins also missed practice as the receiver group thins.
• FanDuel lists San Francisco as a modest favorite in a higher-total game, with Jacksonville entering with a top-10 defense and rookie Travis Hunter contributing on both sides of the ball.