Overview
- Head coach Kyle Shanahan said Purdy will start Sunday in Arizona after practicing, and Purdy told reporters he is "ready to roll."
- The quarterback has played two games this season because of a toe injury, posting 586 yards with four touchdowns and four interceptions.
- Mac Jones went 5-3 as the fill-in, completing 69.6% of his passes for 2,151 yards, 13 touchdowns and six interceptions with a 97.4 passer rating.
- San Francisco, now 6-4, has struggled to generate explosives downfield, going 3-for-16 on 20-plus-yard throws over the past six games as coaches seek a vertical lift.
- Arizona will be without top receiver Marvin Harrison Jr. following appendicitis surgery, with Zay Jones and Simi Fehoko on injured reserve, and Jacoby Brissett set for another start with Kyler Murray on IR.