Overview
- San Francisco opened Week 6 without Brock Purdy, who sat out practice because of a persistent toe injury.
- Kyle Shanahan said putting Purdy on injured reserve "hasn't been a thought" and described the quarterback as progressing.
- Mac Jones was limited by knee and oblique issues but is expected to be available to start if needed, entering 3-0 as a starter this season.
- Third-string quarterback Adrian Martinez, added to the 53-man roster in Week 5, is receiving starter reps as an emergency option.
- Receivers Ricky Pearsall and Jauan Jennings remained out; safety Malik Mustapha practiced fully and expects to play, DT Kevin Givens was limited, and Eddy Piñeiro was named NFC Special Teams Player of the Week.