49ers' Isaac Guerendo Suffers Knee and Ankle Injury in Season Finale

The rookie running back was carted off the field during the first quarter, capping a challenging season for San Francisco.

Isaac Guerendo, a fourth-round rookie running back, sustained a knee and ankle injury early in the 49ers' Week 18 loss to the Arizona Cardinals and was immediately ruled out of the game.
Head coach Kyle Shanahan stated that Guerendo likely suffered an MCL sprain but further testing is needed to rule out an ACL injury.
Guerendo finished his rookie season with 415 rushing yards and four touchdowns, stepping into a lead role due to injuries in the 49ers' running back rotation.
The game also saw Jauan Jennings ejected in the second quarter after two consecutive personal fouls during blocking plays, leaving him just 25 yards shy of a career milestone of 1,000 receiving yards.
The 49ers concluded their season with a 6-11 record and will hold the 11th overall pick in the upcoming NFL Draft.