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49ers Host Undefeated Cardinals With Brock Purdy Inactive for Week 3

San Francisco will turn to its quarterback depth against a 2-0 Arizona team coping with defensive injuries.

Overview

  • Kickoff is 4:25 p.m. ET at Levi's Stadium on FOX, with streaming available on Fubo and other services that carry FOX.
  • With Brock Purdy ruled out, Mac Jones is next up after throwing three touchdowns and 279 yards in Week 2.
  • Sportsbooks list San Francisco as the favorite, including BetMGM at 49ers -1.5, and a SportsLine model projects a 55% chance they cover.
  • Arizona opened 2-0 behind efficient play from Kyler Murray and now visits with several injuries on defense.
  • The Cardinals swept the 49ers last season, and Adam Amin and Mark Sanchez are assigned to call today’s broadcast.