Overview
- Kickoff is 4:25 p.m. ET at Levi's Stadium on FOX, with streaming available on Fubo and other services that carry FOX.
- With Brock Purdy ruled out, Mac Jones is next up after throwing three touchdowns and 279 yards in Week 2.
- Sportsbooks list San Francisco as the favorite, including BetMGM at 49ers -1.5, and a SportsLine model projects a 55% chance they cover.
- Arizona opened 2-0 behind efficient play from Kyler Murray and now visits with several injuries on defense.
- The Cardinals swept the 49ers last season, and Adam Amin and Mark Sanchez are assigned to call today’s broadcast.