Overview
- Kickoff is 8:15 p.m. ET at Levi's Stadium in Santa Clara, with the game airing on ESPN.
- San Francisco enters 7-4 after a 41-22 win over Arizona, while Carolina is 6-5 following a 30-27 overtime victory at Atlanta.
- Sportsbooks list the 49ers around -7.5 with a total near 49.5 points, and money lines reported near 49ers -395 and Panthers +305.
- Final Week 12 injury reports include 49ers LB Tatum Bethune ruled out, with Brock Purdy and key pass-catchers available.
- CBS Sports cites defensive concerns for San Francisco, including a league-low sack total and few interceptions, a factor weighed against Bryce Young and RB Rico Dowdle.