Overview
- Kickoff is 8:15 p.m. ET at Levi's Stadium, with the Panthers entering 6-5 and the 49ers 7-4.
- The 49ers ruled out LB Tatum Bethune and K Eddy Piñeiro and downgraded DE Robert Beal Jr. to out after he remained in concussion protocol.
- San Francisco signed kicker Matt Gay to the practice squad and released WR Russell Gage Jr. from the practice squad.
- Sportsbooks list the 49ers around -7.5 with a total near 49.5, and the SportsLine model projects about 52 combined points and leans Over.
- Expert pick roundups from multiple outlets largely back San Francisco, though previews note the 49ers’ defense has struggled to generate sacks and takeaways.