Overview
- Kickoff is set for 4:05 p.m. ET at Levi's Stadium in Santa Clara on FOX, with streaming on Fubo and Sling.
- The 49ers enter 3-0 after three one-score wins, while the Jaguars are 2-1 following a victory over Houston.
- San Francisco plays without edge rusher Nick Bosa for the season, prompting calls for more pressure packages to compensate.
- Jacksonville has led the league in takeaways early, averaging three per game with seven interceptions through the first three weeks.
- The 49ers have struggled to finish drives, ranking 24th in red-zone touchdown rate as Christian McCaffrey has seven rushing yards on 13 red-zone carries.