Overview
- The game kicks off Monday, Oct. 19 at 8:15 p.m. ET from Levi’s Stadium and will be broadcast on ESPN with streaming available on DIRECTV, the ESPN app and Fubo.
- Betting markets have moved in favor of San Francisco with the 49ers listed as 7.5-point favorites, a DraftKings moneyline of -455 and a game total of 52.5.
- Washington will be without QB Marcus Mariota, while the 49ers ruled out WR Deebo Samuel and DE Nick Bosa and listed WR Mike Evans as questionable, making late availability a key factor.
- Brock Purdy enters with heavy MVP attention after 13 TDs and two interceptions through five games and the 49ers’ offensive efficiency faces a test against a Commanders defense that recently allowed 326 passing yards to Jameis Winston and 95 rushing yards to Jonathan Taylor.
- The injury-driven matchup changes matter for game plans, prop markets and fantasy lineups and further highlight how San Francisco’s depth has carried its unbeaten start into Week 6.