Overview

• Kickoff is 4:25 p.m. ET/1:25 p.m. PT on FOX (KTVU in the Bay Area), with streaming options including NFL+, Fubo, YouTube TV and DirecTV Stream.
• Head coach Kyle Shanahan said it is highly unlikely Brock Purdy will start as he manages a toe injury after limited practices.
• Mac Jones started last week and completed 26 of 39 passes for 279 yards with three touchdowns and no interceptions in a 26-21 win.
• San Francisco remains without tight end George Kittle for multiple weeks and wide receiver Brandon Aiyuk until after Week 4.
• Both teams are 2-0, and the winner moves to 3-0 with a chance to gain early control of the NFC West.