Overview

• The NFC West matchup is at Levi's Stadium in Santa Clara with both teams entering 2-0 and early divisional positioning in play.
• Jones is projected to replace Brock Purdy, who is managing turf toe, after going 26-for-39 for 279 yards and three touchdowns in Week 2.
• San Francisco remains without tight end George Kittle (hamstring) and wide receiver Brandon Aiyuk (knee), each expected to miss multiple weeks.
• The game airs nationally on FOX, with local coverage on KTVU in the Bay Area and KSAZ in Phoenix, and streaming options including Fubo and NFL+.
• Oddsmakers give the 49ers a slight edge, including -3 at DraftKings and about -1.5 at BetMGM, with over/under figures near 43.5.