Overview

• Kickoff is 4:25 p.m. ET at Levi's Stadium on Fox with streaming on NFL+.
• Both teams are 2-0, and the winner will move to 3-0 in the division race.
• Mac Jones will be under center after throwing for 279 yards and three touchdowns without an interception last week.
• Brock Purdy is dealing with turf toe, George Kittle (hamstring) is expected to miss multiple weeks, and Brandon Aiyuk (knee) is not eligible to return until after Week 4.
• Betting lines list San Francisco as a slight favorite (around -3, total 43.5), with fantasy guidance to start Christian McCaffrey, consider Ricky Pearsall as a flex, and avoid streaming the 49ers defense against Kyler Murray.