Overview
- DraftKings lists San Francisco as a 12.5-point favorite over Tennessee, reflecting broad expectations of a lopsided matchup.
- The 49ers are 9-4 with roughly a 93% playoff probability per NFL.com and seek a fourth straight win after their late bye.
- Final injury report: Christian McCaffrey and Kyle Juszczyk are cleared to play, while Tatum Bethune, Sam Okuayinonu and Nick Martin are out and Yetur Gross-Matos will not be activated.
- Coaches and analysts emphasize Purdy taking care of the ball, pointing to his turnover-averse performance against Cleveland and a strong track record in games following byes.
- Tennessee’s passing game is high volume but inefficient with rookie Cam Ward taking a league-high 49 sacks, and special teams could matter as the 49ers have sprung multiple long Skyy Moore returns even against solid Titans coverage units.