Overview
- Kickoff is Sunday at 4:25 p.m. ET at Levi's Stadium on Fox with streaming on Fubo, and DraftKings lists San Francisco as a 12.5-point favorite with a 44.5 over/under.
- The 49ers enter one game back in the NFC West race and look to solidify playoff seeding coming off their late-season bye.
- Tennessee is 2-11 after a 31-29 upset of the Browns in Week 14 and still factors into the race for the No. 1 pick in the 2026 NFL Draft.
- Previews expect Kyle Shanahan and Brock Purdy to target Tennessee’s struggling secondary, noting Purdy’s strong post-bye track record and projecting a productive San Francisco offense.
- Analysts describe Titans rookie Cam Ward as improving yet vulnerable to interior pressure, and they note San Francisco’s success against rookie QBs even as the 49ers play without injured defensive stars Nick Bosa, Mykel Williams and Fred Warner.