Overview

• Warner was injured with 7:48 left in the first quarter on Rachaad White’s 10-yard run when safety Ji’Ayir Brown rolled into his right ankle.
• Medical staff applied an air cast and carted him to the locker room, and the 49ers quickly declared him out for the game.
• Tatum Bethune entered at middle linebacker as San Francisco reworked its defensive communication on the fly.
• The loss compounds an already heavy injury toll for the 49ers, including Nick Bosa’s season-ending ACL tear and missed time for Brock Purdy, George Kittle and several receivers.
• Outside medical voices have speculated about a fracture or dislocation that could require surgery, but the team has not issued a diagnosis or timeline.