Overview
- San Francisco (8-4) visits Cleveland (3-8) on Sunday at 1 p.m. EST on CBS, with BetMGM listing the 49ers by 5 points and other books near 5.5–6.
- Brock Purdy is coming off a three-interception first half in Week 12 and now meets a Browns defense ranked No. 2 overall.
- Rookie quarterback Shedeur Sanders gets his second start for Cleveland after winning his debut, as the Browns seek consecutive wins for the first time since 2023.
- Myles Garrett leads the NFL with 18 sacks, including 14 over his past five games, and Cleveland logged 10 sacks in its most recent outing.
- Key injuries to monitor include 49ers DE Sam Okuayinonu (ankle) with status in question, LB Tatum Bethune and K Eddy Piñeiro likely out, and Browns DT Adin Huntington and TE Brenden Bates expected to sit.